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Not just its sum but additionally the useful Houses of Hb have an affect on general performance. This can be illustrated with the observation that an increased Hb-O2 affinity favors O2 loading from the lung and survival within an hypoxic setting (Eaton et al., 1974; Hebbel et al., 1978), whereas a reduced Hb-O2 affinity favors the release of O2 fro